Bacteriologic studies of skin, tissue fluid, lymph, and lymph nodes in patients with filarial lymphedema
Identifieur interne : 00BC13 ( Main/Exploration ); précédent : 00BC12; suivant : 00BC14Bacteriologic studies of skin, tissue fluid, lymph, and lymph nodes in patients with filarial lymphedema
Auteurs : W. L. Olszewski [Pologne, Inde] ; S. Jamal ; G. Manokaran ; S. Pani ; V. Kumaraswami ; U. Kubicka ; B. Lukomska ; A. Dworczynski ; E. Swoboda ; E. Meisel-MikolajczykSource :
- The American journal of tropical medicine and hygiene [ 0002-9637 ] ; 1997.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Antibactériens (pharmacologie), Bactéries (), Bactéries (isolement et purification), Bactériémie (microbiologie), Femelle, Filariose lymphatique (anatomopathologie), Filariose lymphatique (microbiologie), Humains, Liquides biologiques (microbiologie), Lymphe (microbiologie), Mâle, Noeuds lymphatiques (microbiologie), Numération de colonies microbiennes, Peau (microbiologie), Tests de sensibilité microbienne.
- MESH :
- anatomopathologie : Filariose lymphatique.
- isolement et purification : Bactéries.
- microbiologie : Bactériémie, Filariose lymphatique, Liquides biologiques, Lymphe, Noeuds lymphatiques, Peau.
- pharmacologie : Antibactériens.
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
- Adolescent, Adult, Anti-Bacterial Agents (pharmacology), Bacteremia (microbiology), Bacteria (drug effects), Bacteria (isolation & purification), Bacteriological investigation, Body Fluids (microbiology), Colony Count, Microbial, Elephantiasis, Filarial (microbiology), Elephantiasis, Filarial (pathology), Female, Filariosis, Human, Humans, India, Lymph, Lymph (microbiology), Lymph Nodes (microbiology), Lymph node, Lymphatic system, Lymphedema, Male, Microbial Sensitivity Tests, Middle Aged, Skin, Skin (microbiology).
- MESH :
- chemical , pharmacology : Anti-Bacterial Agents.
- drug effects : Bacteria.
- isolation & purification : Bacteria.
- microbiology : Bacteremia, Body Fluids, Elephantiasis, Filarial, Lymph, Lymph Nodes, Skin.
- pathology : Elephantiasis, Filarial.
- Adolescent, Adult, Colony Count, Microbial, Female, Humans, Male, Microbial Sensitivity Tests, Middle Aged.
Abstract
Filarial lymphedema is complicated by frequent episodes of dermatolymphangioadenitis (DLA). It is not certain whether DLA is of filarial or bacterial etiology. The frequency of episodic DLA does not depend on the presence or absence of microfilariae. Antibiotic therapy is effective in prevention and treatment of DLA. These observations point to the bacterial rather than filarial etiology of DLA. Skin and lymph node biopsies, tissue fluid, lymph, and blood from patients with chronic filarial lymphedema, and during acute episodes of DLA, were cultured for detection of bacteria. A high prevalence of bacterial isolates from the tissue fluid (64%), lymph (75%), and inguinal lymph nodes (66%) of limbs with filarial lymphedema was found. Bacillus cereus, Staphylococcus epidermidis, S. hominis, S. capitis, S. xylosus, and Micrococcus spp. were the most common isolates. Bacteria were also isolated from the blood of patients with recent episodes of DLA, with strains of the same phenotype and antibiotic sensitivity in all specimens from patients with DLA. Bacterial strains of the same phenotype and antibiotic sensitivity were documented on the toe web surface and in tissue fluid (25%), lymph (26%), or lymph nodes (41%). Increasing prevalence of bacterial isolates in tissue fluid, lymph, and lymph nodes was observed in advanced stages of lymphedema. Bacilli and cocci were sensitive to gentamicin, tetracyline, rifampicin, vancomycin, kanamycin and cotrimoxazole, and least sensitive to penicillin. Blood cultures of patients in the periods between DLA attacks were negative. In healthy controls without edema and episodes of DLA, tissue fluid did not contain bacteria. In lymph, only single colonies of Micrococcus and Acinetobacter were cultured in 12% of the cases. Impaired lymph drainage and lack of elimination of penetrating bacteria may be responsible for progression of lymphedema and recurrent attacks of DLA.
Affiliations:
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L." last="Olszewski">W. L. Olszewski</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Surgical Research, Medical Research Center, Polish Academy of Sciences</s1><s2>Warsaw</s2><s3>POL</s3></inist:fA14><country>Pologne</country><wicri:noRegion>Warsaw</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Thanjavur Medical College</s1><s2>Thanjavur</s2><s3>IND</s3></inist:fA14><country>Inde</country><wicri:noRegion>Thanjavur Medical College</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Apollo Hospitals</s1><s2>Madras</s2><s3>IND</s3></inist:fA14><country>Inde</country><wicri:noRegion>Apollo Hospitals</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Vector Control Research Center, Indian Council for Medical Research (ICMR)</s1><s2>Pondicherry</s2><s3>IND</s3></inist:fA14><country>Inde</country><wicri:noRegion>Pondicherry</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Tuberculosis Research Center, ICMR</s1><s2>Madras</s2><s3>IND</s3></inist:fA14><country>Inde</country><wicri:noRegion>Madras</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Clinical Bacteriology, Medical Academy</s1><s2>Warsaw</s2><s3>POL</s3></inist:fA14><country>Pologne</country><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Jamal, S" sort="Jamal, S" uniqKey="Jamal S" first="S." last="Jamal">S. Jamal</name></author><author><name sortKey="Manokaran, G" sort="Manokaran, G" uniqKey="Manokaran G" first="G." last="Manokaran">G. Manokaran</name></author><author><name sortKey="Pani, S" sort="Pani, S" uniqKey="Pani S" first="S." last="Pani">S. Pani</name></author><author><name sortKey="Kumaraswami, V" sort="Kumaraswami, V" uniqKey="Kumaraswami V" first="V." last="Kumaraswami">V. Kumaraswami</name></author><author><name sortKey="Kubicka, U" sort="Kubicka, U" uniqKey="Kubicka U" first="U." last="Kubicka">U. Kubicka</name></author><author><name sortKey="Lukomska, B" sort="Lukomska, B" uniqKey="Lukomska B" first="B." last="Lukomska">B. Lukomska</name></author><author><name sortKey="Dworczynski, A" sort="Dworczynski, A" uniqKey="Dworczynski A" first="A." last="Dworczynski">A. Dworczynski</name></author><author><name sortKey="Swoboda, E" sort="Swoboda, E" uniqKey="Swoboda E" first="E." last="Swoboda">E. Swoboda</name></author><author><name sortKey="Meisel Mikolajczyk, E" sort="Meisel Mikolajczyk, E" uniqKey="Meisel Mikolajczyk E" first="E." last="Meisel-Mikolajczyk">E. Meisel-Mikolajczyk</name></author></analytic><series><title level="j" type="main">The American journal of tropical medicine and hygiene</title><title level="j" type="abbreviated">Am. j. trop. med. hyg.</title><idno type="ISSN">0002-9637</idno><imprint><date when="1997">1997</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The American journal of tropical medicine and hygiene</title><title level="j" type="abbreviated">Am. j. trop. med. hyg.</title><idno type="ISSN">0002-9637</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Anti-Bacterial Agents (pharmacology)</term><term>Bacteremia (microbiology)</term><term>Bacteria (drug effects)</term><term>Bacteria (isolation & purification)</term><term>Bacteriological investigation</term><term>Body Fluids (microbiology)</term><term>Colony Count, Microbial</term><term>Elephantiasis, Filarial (microbiology)</term><term>Elephantiasis, Filarial (pathology)</term><term>Female</term><term>Filariosis</term><term>Human</term><term>Humans</term><term>India</term><term>Lymph</term><term>Lymph (microbiology)</term><term>Lymph Nodes (microbiology)</term><term>Lymph node</term><term>Lymphatic system</term><term>Lymphedema</term><term>Male</term><term>Microbial Sensitivity Tests</term><term>Middle Aged</term><term>Skin</term><term>Skin (microbiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antibactériens (pharmacologie)</term><term>Bactéries ()</term><term>Bactéries (isolement et purification)</term><term>Bactériémie (microbiologie)</term><term>Femelle</term><term>Filariose lymphatique (anatomopathologie)</term><term>Filariose lymphatique (microbiologie)</term><term>Humains</term><term>Liquides biologiques (microbiologie)</term><term>Lymphe (microbiologie)</term><term>Mâle</term><term>Noeuds lymphatiques (microbiologie)</term><term>Numération de colonies microbiennes</term><term>Peau (microbiologie)</term><term>Tests de sensibilité microbienne</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Bacterial Agents</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Bacteria</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Bacteria</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Bactéries</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Bactériémie</term><term>Filariose lymphatique</term><term>Liquides biologiques</term><term>Lymphe</term><term>Noeuds lymphatiques</term><term>Peau</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Bacteremia</term><term>Body Fluids</term><term>Elephantiasis, Filarial</term><term>Lymph</term><term>Lymph Nodes</term><term>Skin</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antibactériens</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Colony Count, Microbial</term><term>Female</term><term>Humans</term><term>Male</term><term>Microbial Sensitivity Tests</term><term>Middle Aged</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Bactéries</term><term>Femelle</term><term>Humains</term><term>Lymphoedème</term><term>Filariose</term><term>Mâle</term><term>Numération de colonies microbiennes</term><term>Système lymphatique</term><term>Exploration bactériologique</term><term>Peau</term><term>Ganglion lymphatique</term><term>Lymphe</term><term>Homme</term><term>Inde</term><term>Tests de sensibilité microbienne</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Inde</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Filarial lymphedema is complicated by frequent episodes of dermatolymphangioadenitis (DLA). It is not certain whether DLA is of filarial or bacterial etiology. The frequency of episodic DLA does not depend on the presence or absence of microfilariae. Antibiotic therapy is effective in prevention and treatment of DLA. These observations point to the bacterial rather than filarial etiology of DLA. Skin and lymph node biopsies, tissue fluid, lymph, and blood from patients with chronic filarial lymphedema, and during acute episodes of DLA, were cultured for detection of bacteria. A high prevalence of bacterial isolates from the tissue fluid (64%), lymph (75%), and inguinal lymph nodes (66%) of limbs with filarial lymphedema was found. Bacillus cereus, Staphylococcus epidermidis, S. hominis, S. capitis, S. xylosus, and Micrococcus spp. were the most common isolates. Bacteria were also isolated from the blood of patients with recent episodes of DLA, with strains of the same phenotype and antibiotic sensitivity in all specimens from patients with DLA. Bacterial strains of the same phenotype and antibiotic sensitivity were documented on the toe web surface and in tissue fluid (25%), lymph (26%), or lymph nodes (41%). Increasing prevalence of bacterial isolates in tissue fluid, lymph, and lymph nodes was observed in advanced stages of lymphedema. Bacilli and cocci were sensitive to gentamicin, tetracyline, rifampicin, vancomycin, kanamycin and cotrimoxazole, and least sensitive to penicillin. Blood cultures of patients in the periods between DLA attacks were negative. In healthy controls without edema and episodes of DLA, tissue fluid did not contain bacteria. In lymph, only single colonies of Micrococcus and Acinetobacter were cultured in 12% of the cases. Impaired lymph drainage and lack of elimination of penetrating bacteria may be responsible for progression of lymphedema and recurrent attacks of DLA.</div></front></TEI><affiliations><list><country><li>Inde</li><li>Pologne</li></country></list><tree><noCountry><name sortKey="Dworczynski, A" sort="Dworczynski, A" uniqKey="Dworczynski A" first="A." last="Dworczynski">A. Dworczynski</name><name sortKey="Jamal, S" sort="Jamal, S" uniqKey="Jamal S" first="S." last="Jamal">S. Jamal</name><name sortKey="Kubicka, U" sort="Kubicka, U" uniqKey="Kubicka U" first="U." last="Kubicka">U. Kubicka</name><name sortKey="Kumaraswami, V" sort="Kumaraswami, V" uniqKey="Kumaraswami V" first="V." last="Kumaraswami">V. Kumaraswami</name><name sortKey="Lukomska, B" sort="Lukomska, B" uniqKey="Lukomska B" first="B." last="Lukomska">B. Lukomska</name><name sortKey="Manokaran, G" sort="Manokaran, G" uniqKey="Manokaran G" first="G." last="Manokaran">G. Manokaran</name><name sortKey="Meisel Mikolajczyk, E" sort="Meisel Mikolajczyk, E" uniqKey="Meisel Mikolajczyk E" first="E." last="Meisel-Mikolajczyk">E. Meisel-Mikolajczyk</name><name sortKey="Pani, S" sort="Pani, S" uniqKey="Pani S" first="S." last="Pani">S. Pani</name><name sortKey="Swoboda, E" sort="Swoboda, E" uniqKey="Swoboda E" first="E." last="Swoboda">E. Swoboda</name></noCountry><country name="Pologne"><noRegion><name sortKey="Olszewski, W L" sort="Olszewski, W L" uniqKey="Olszewski W" first="W. L." last="Olszewski">W. L. Olszewski</name></noRegion><name sortKey="Olszewski, W L" sort="Olszewski, W L" uniqKey="Olszewski W" first="W. L." last="Olszewski">W. L. Olszewski</name></country><country name="Inde"><noRegion><name sortKey="Olszewski, W L" sort="Olszewski, W L" uniqKey="Olszewski W" first="W. L." last="Olszewski">W. L. Olszewski</name></noRegion><name sortKey="Olszewski, W L" sort="Olszewski, W L" uniqKey="Olszewski W" first="W. L." last="Olszewski">W. L. Olszewski</name><name sortKey="Olszewski, W L" sort="Olszewski, W L" uniqKey="Olszewski W" first="W. L." last="Olszewski">W. L. Olszewski</name><name sortKey="Olszewski, W L" sort="Olszewski, W L" uniqKey="Olszewski W" first="W. L." last="Olszewski">W. L. Olszewski</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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